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ugd [2019-02-27 17:31:05]
UDP-glucose dehydrogenase
product
UDP-glucose dehydrogenase
Genomic Context
categories
[category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.7|Phosphorylation on a Tyr residue]Gene
Coordinates
3,729,488 3,730,810
The protein
Catalyzed reaction/ biological activity
UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH (according to Swiss-Prot)Protein family
UDP-glucose/GDP-mannose dehydrogenase family (according to Swiss-Prot)Paralogous protein(s)
[protein|59024C05AA0106719C81E45E3B060A6F710B2690|YtcA], [protein|DF8CD0B3997A7A4CF4821A7D64E9898422FD17E0|TuaD] Modification
phosphorylation on Tyr-70 by [protein|6100EA37592A2C31BC3DE79AD7948A8D6F65F6E1|PtkA] [Pubmed|12970183], dephosphorylated by [protein|CF73D86DB024575BE8F043A4C3996458F4262E46|PtpZ] [Pubmed|15866923]Effectors of protein activity
phosphorylation by [protein|6100EA37592A2C31BC3DE79AD7948A8D6F65F6E1|PtkA] stimulates activity of Ugd [Pubmed|15741737][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|8DCA50478136628DD9E5D01E89609A686EED9F57|tkmA]-[gene|6100EA37592A2C31BC3DE79AD7948A8D6F65F6E1|ptkA]-[gene|CF73D86DB024575BE8F043A4C3996458F4262E46|ptpZ]-[gene|45AFD434F5262BFBE4ED6DF3D18DAED61FF317D1|ugd]
description
[Pubmed|20815827,12970183]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|20815827], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A]: activation, [Pubmed|26283769], in [regulon|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A regulon][protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]-P, [Pubmed|26283769], in [regulon|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU regulon][protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|20817675], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]view in new tabBiological materials
Mutant
BKE36230 ([gene|45AFD434F5262BFBE4ED6DF3D18DAED61FF317D1|ugd]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE36230 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTTTCCCTCCAACAGT, downstream forward: _UP4_TAGATGAAAAAGAAAGGCTGReferences
12970183,19258708,15741737,15866923,20815827,24728941,26283769